The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

imageimageThis study identifies Ki-67 as a critical modulator of the intensity of pro-inflammatory gene expression governing neutrophil recruitment during respiratory infections. The severity of ...

Oral leukoplakia (OLK) is the most prevalent oral potentially malignant disorder (OPMD) in clinical practice (Kerr and Lodi, 2021).Its prevalence is reported to be 0.5% to 3.46%, and its malignant ...

Histone posttranslational modifications (PTMs) such as ubiquitination, methylation and phosphorylation play a crucial role in gene transcription, DNA replication and repair (Chen and Tyler, 2022; ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

In this study, we demonstrated that the druggable NCoR1/RARα axis is a promising target for selective inhibition of CMA in NSCLC. Furthermore, we developed CIM7, a first-in-class small molecule ...

Telomerase deficiency in humans results in the development of telomere biology disorders (TBDs) that include idiopathic pulmonary fibrosis, dyskeratosis congenita and aplastic anemia (Armanios, ...

The Cryo-EM structures of oligomeric F 1 F 0-ATP synthases demonstrated that If1 dimers, could bridge adjacent F 1 F 0-ATP synthase dimers, suggesting that If1 could stabilize oligomers (Cabezón et al ...

Direct measurement of metabolic and transcriptional biomarkers in the gut is also challenging. The brevity of bacterial mRNA half-lives, which can average less than a minute (Jenniches et al, 2024), ...

Here we focus on a highly conserved 9 nt microexon in the synaptic vesicle gene unc-13, which we find is completely included in motor neurons, but completely skipped in olfactory neurons.We identify a ...