The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

In “Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor” by Singh et al, 2019, and “Transcript-specific induction of stop codon readthrough using a ...

Chloride (Cl −) ions cause major damage to crops in saline soils.Understanding the key factors that influence Cl − uptake and translocation will aid the breeding of more salt-tolerant crops. Here, ...

Stroke is a major public health concern with a vast socioeconomic burden (Virani et al, 2021).Stroke is also the second leading cause of death and a leading cause of long‐term disability worldwide ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

Arabidopsis genome encodes approximately 60 putative MAPKKKs, 10 MAPKKs, and 20 MAPKs (MAPK‐Group, 2002).MAPK cascades have been shown to regulate diverse aspects of plant biology, including plant ...

In this study, we demonstrated that the druggable NCoR1/RARα axis is a promising target for selective inhibition of CMA in NSCLC. Furthermore, we developed CIM7, a first-in-class small molecule ...

It has been demonstrated that extrinsic factors play an essential role in the activation of EMH (Short et al, 2019).Overexpression of Tlx1, a transcription factor expressed in spleen stromal cells, ...

Telomerase deficiency in humans results in the development of telomere biology disorders (TBDs) that include idiopathic pulmonary fibrosis, dyskeratosis congenita and aplastic anemia (Armanios, ...

Histone posttranslational modifications (PTMs) such as ubiquitination, methylation and phosphorylation play a crucial role in gene transcription, DNA replication and repair (Chen and Tyler, 2022; ...

Here we focus on a highly conserved 9 nt microexon in the synaptic vesicle gene unc-13, which we find is completely included in motor neurons, but completely skipped in olfactory neurons.We identify a ...

Oral leukoplakia (OLK) is the most prevalent oral potentially malignant disorder (OPMD) in clinical practice (Kerr and Lodi, 2021).Its prevalence is reported to be 0.5% to 3.46%, and its malignant ...