The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

In “Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor” by Singh et al, 2019, and “Transcript-specific induction of stop codon readthrough using a ...

We recently showed that the VACV membrane is organized into distinct functional domains; with EFCs polarized to the tips of virions and binding proteins A27 and D8 relegated to the sides of virions ...

Paraneoplastic syndrome represents a diverse array of clinical manifestations occurring in multiple organs of cancer patients, which are not directly attributable to tumor burden or invasion (Kannoth, ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

Given the link to antiviral defenses, viruses have developed strategies to disrupt stress granule formation and even hijacked these factors to facilitate their replication (Eiermann et al, 2020; ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...

CIITA transcription itself is controlled by a 14 kb multi-promoter regulatory region, containing three independent promoter elements in humans, pI, pIII, and pIV, which are expressed in a ...

In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

Chloride (Cl −) ions cause major damage to crops in saline soils.Understanding the key factors that influence Cl − uptake and translocation will aid the breeding of more salt-tolerant crops. Here, ...